Errata corrigenda!

This paper is a review on anti-G protein-coupled receptors antibodies in rheumatic diseases. Beta-adrenergic receptors and muscarinic receptors belong to this important class of membrane proteins. I was eager to check if they had included ME/CFS among those diseases associated with this kind of autoantibodies, but I was skeptical. I was surprised to read that, in fact, they mentioned ME/CFS (they call it CFS) in table I, along with Sjögren, Systemic Sclerosis and other autoimmune diseases. But there are some mistakes: they correctly cited the paper by Loebel and colleagues, but they associated CFS with the wrong type of antibodies. Loebel et al. found that the only association that was statistically significant was with anti-beta 2 adrenergic receptors, and anti-M3/M4 muscarinic receptors (you can read that even from the abstract) while in this paper CFS has been associated with anti-beta 1, but not with anti-beta 2, and with antibodies to all the first 4 subtypes of muscarinic receptors. Moreover, they forgot to mention both the paper by Tanaka S et al. and the work by Yamamoto S et al., where an association with anti-M1 was reported. I wrote a mail to one of the authors, but she never answered. The journal is Nature Reviews, Rheumatology.

4 pensieri su “Errata corrigenda!

    1. ME/CFS non è uguale a Borrelia, non ci sono studi a sostegno di questo mito. Ma è vero che alcuni pazienti che hanno avuto contatto con B. burgdorferi sviluppano una classica ME/CFS. Sono una esigua minoranza, in base ai dati disponibili.

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